Graphic evaluation for cardiovascular circulation data in clinical trials

Presented: Thursday, July 17, 2008
Speaker: Ihab G. Girgis; Johnson & Johnson Pharmaceutical R&D

There are other unknown factors that influence this interval, making it highly variable across population and the analysis of such data is complex. In order to evaluate the effect of drug on QT interval, accurate modeling of drug-free baseline QT becomes an important first step; the changes to this baseline model after the administration of investigational drug will reflect the effect of the investigational drug on the QT/QTc interval.

This work focuses on the graphical evaluation of baseline QT clinical data and its modeling. A hierarchical Bayesian approach has been used. The QT-RR relationship is explored using various models and performance of the models is evaluated in comparison to well-known correlation methods (Bazett, Fridericia, Framingham, Hodge and individual correction). Finally, diverse nonlinear functions, ranging from a simple cosine function to multi-harmonics Fourier series are tested to describe the circadian rhythm effect.

Speeding up analysis and reporting process – analytic reporting with Tibco spotfire

Date Recorded: Thursday, September 25, 2008
Speaker: Michael O’Connell, Insightful Corporation
Times: On-Demand

SAS® software and S-PLUS are widely used together in data analysis environments. A typical use case involves the SAS data step for data transformation and PROC Tabulate to provide simple tabular summaries; and S-PLUS to provide graphical summaries and additional analytics, e.g. survival analysis, from the transformed SAS datasets.

This web cast describes the use of S-PLUS and Insightful Solutions for end-to-end graphical and tabular reporting including:

The S-PLUS Connector for SAS – batch analyses using S-PLUS and SAS software, including combining S-PLUS graphics with SAS tabular output e.g. as SAS ODS html, and automated integration of S-PLUS and SAS verbose log files.
Insightful Clinical Study Reporting – static, pixel-perfect reporting for study reports and regulatory submissions.
Insightful Clinical Review – interactive graphical and tabular reports for exploratory analysis, data cleaning and review of clinical trials.
Insightful Clinical Graphics – point-click graphics with generated S-PLUS code for clinical data analysis and reporting
S-PLUS and SAS software together provide a highly efficient environment for exploratory and production analysis and reporting, leveraging the strengths of each tool. The Insightful Solutions provide automated processes and software for standardized study reports that save time, standardize best practices, remove manual errors and allow high-value professionals to spend their time advancing their research programs rather than spending time churning through manual graphics and reporting tasks.

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Insightful offers data analysis consulting services from statistical analysis and model building, to custom application development, to end-to-end system integration. Drawing on its technical consulting and research staff of software engineers, statisticians, and scientists (including 50 Ph.d.’s), Insightful has the expertise to tackle large scale and challenging problems involving data and statistical analysis.

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Insightful Corporation offers a range of statistical data analysis and data mining products for administrators, faculty members, institutional researchers and students. We offer competitive pricing and a range of licensing options to help you easily integrate our products into curricula for research, graduate and undergraduate uses.
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