There are other unknown factors that influence this interval, making it highly variable across population and the analysis of such data is complex. In order to evaluate the effect of drug on QT interval, accurate modeling of drug-free baseline QT becomes an important first step; the changes to this baseline model after the administration of investigational drug will reflect the effect of the investigational drug on the QT/QTc interval.

This work focuses on the graphical evaluation of baseline QT clinical data and its modeling. A hierarchical Bayesian approach has been used. The QT-RR relationship is explored using various models and performance of the models is evaluated in comparison to well-known correlation methods (Bazett, Fridericia, Framingham, Hodge and individual correction). Finally, diverse nonlinear functions, ranging from a simple cosine function to multi-harmonics Fourier series are tested to describe the circadian rhythm effect.

SAS® software and S-PLUS are widely used together in data analysis environments. A typical use case involves the SAS data step for data transformation and PROC Tabulate to provide simple tabular summaries; and S-PLUS to provide graphical summaries and additional analytics, e.g. survival analysis, from the transformed SAS datasets.

This web cast describes the use of S-PLUS and Insightful Solutions for end-to-end graphical and tabular reporting including:

The S-PLUS Connector for SAS – batch analyses using S-PLUS and SAS software, including combining S-PLUS graphics with SAS tabular output e.g. as SAS ODS html, and automated integration of S-PLUS and SAS verbose log files.
Insightful Clinical Study Reporting – static, pixel-perfect reporting for study reports and regulatory submissions.
Insightful Clinical Review – interactive graphical and tabular reports for exploratory analysis, data cleaning and review of clinical trials.
Insightful Clinical Graphics – point-click graphics with generated S-PLUS code for clinical data analysis and reporting
S-PLUS and SAS software together provide a highly efficient environment for exploratory and production analysis and reporting, leveraging the strengths of each tool. The Insightful Solutions provide automated processes and software for standardized study reports that save time, standardize best practices, remove manual errors and allow high-value professionals to spend their time advancing their research programs rather than spending time churning through manual graphics and reporting tasks.

The technical support team is dedicated to providing responsive, effective support that helps our customers use Insightful products effectively.

Goals
The technical support team is committed to:

Minimizing customer response time.
Ensuring customer satisfaction by having pleasant, responsive, qualified people work on each customer communication.
Delivering effective answers as quickly as possible.
Providing customers with ongoing updates of unresolved problems.

Important Information Prior to Calling

For fastest service, please have the following handy when you contact technical support:

Your product serial number.
The product serial number can be found on the back of your CD jewel case.
The product serial number can be found by clicking on Help/About…
The product version number.
The product for windows version number can be found by clicking on Help/About…
The S-PLUS for UNIX version number can be found by typing: Splus VERSION from a UNIX prompt, or version from the S-PLUS prompt.
The type and version number of the operating system you are using.
If you are getting error messages, have the exact error messages, and the commands which generated them.

While our group’s core competence is high-end analytics, we have a track record of successful enterprise deployment using the Web to enable frictionless access to information.

Statistical Consulting Expertise:

Analytic Customer Relationship Management
Financial/Business Performance Management
Operations/Production Management
Reporting and Decision Support Systems

Manufacturing
Statistical process control
Survival and reliability analysis
Degradation analysis
Designed experiments and ANOVA
Six Sigma methodology

Finance
Time series analysis
GARCH modeling and volatility forecasting
Robust and nonparametric financial modeling
Time series database management
Environmental statistics
Portfolio optimization

Pharmaceuticals and Health
Survival analysis
Clinical trial design and analysis
Pharmacokinetics
Spatial statistics
Sequential clinical trial analysis
Missing data

Science and Engineering
Signal and image processing
Wavelet analysis
Information retrieval

Image Processing
Search engines

Data Mining and Market Research
Tree modeling
Cluster analysis
Multidimensional scaling
Analysis with Trellis™ graphics
Neural networks
Response modeling

Software Engineering Expertise
Build custom S-PLUS libraries using S-PLUS functions with C, C++, and FORTRAN libraries and graphical user interfaces using the S-PLUS menu and dialog building tools
Develop point-and-click interfaces using JAVA, Visual Basic, Visual C++ and Web programming
Implement client-server software applications using
S-PLUS support for COM/DECOM/ActiveX, S-PLUS DLL’s

S-PLUS Server
Integrate databases with S-PLUS using ODBC, JDBC, S+SDK, or the Informix Universal Server S+DataBlad

Whether you have short-term need to address a mission-critical business problem or an initiative to deploy an analytic solution, Insightful consultants can cost-effectively meet your needs quickly.

Our consultants have backgrounds in mathematics, statistics, data mining software engineering, databases and data warehouses with specific expertise in the S-PLUS product line and client/server enterprise-wide deployment strategies on Windows/NT, UNIX and Linux platforms.